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Article

Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues

1 Mar 2019

Abstract excerpt

Abstract The relative contribution of peripheral and central leptin signalling to the regulation of metabolism and the mechanisms through which leptin affects glucose homeostasis have not been fully elucidated. We generated complementary lines of mice with either leptin receptor (Lepr) knockdown or reconstitution in adipose tissues using Cre-lox methodology. Lepr knockdown mice were modestly lighter and had lower...

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Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Adipose Tissue and Metabolism
Share to Regulation of Appetite and Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30824713
DOI: 10.1038/s41598-019-39498-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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