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Article

OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jan 1998

Wang M Y, Koyama K, Shimabukuro M, Newgard C B, Unger R H

Abstract excerpt

In obese Zucker diabetic fatty (ZDF) rats with mutant leptin receptors, pancreatic islets have an approximately 50-fold increase in fat (TG), overproduce nitric oxide (NO), and lack a normal proinsulin mRNA response to fatty acids. We overexpressed the wild-type full-length "b" isoform of the leptin receptor (OB-Rb) in ZDF islets by perfusing ZDF pancreata with recombinant adenovirus containing the cDNA encoding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9435258
DOI: 10.1073/pnas.95.2.714
PMCID: PMC18486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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