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Article

Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis.

Laboratory investigation; a journal of technical methods and pathology - 1 Apr 1997

Qin Y, Greiner A, Hallas C, Haedicke W, Müller-Hermelink H K

Abstract excerpt

Recent studies have shown that gastric mucosa-associated lymphoid tissue (MALT)-type lymphoma B cells are the malignant counterparts of hypermutated, postgerminal-center memory B cells. To further elucidate the role of antigen selection in the evolution of gastric low-grade MALT-type lymphoma, we analyzed intraclonal variations of the immunoglobulin heavy-chain variable region (Ig VH) genes expressed in three...

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PMID: 9111510

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Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis.PMID 9111510Read ↗

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