Article
Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis.
Laboratory investigation; a journal of technical methods and pathology - 1 Apr 1997
Qin Y, Greiner A, Hallas C, Haedicke W, Müller-Hermelink H K
Abstract excerpt
Recent studies have shown that gastric mucosa-associated lymphoid tissue (MALT)-type lymphoma B cells are the malignant counterparts of hypermutated, postgerminal-center memory B cells. To further elucidate the role of antigen selection in the evolution of gastric low-grade MALT-type lymphoma, we...
Topics
- Base Sequence
- Clone Cells
- Cloning, Molecular
- DNA Primers
- DNA, Neoplasm
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Lymphoma, B-Cell, Marginal Zone
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA, Neoplasm
- Stomach Neoplasms