Article
Immunoglobulin VH genes of high-grade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen-dependent affinity maturation.
Laboratory investigation; a journal of technical methods and pathology - 1 Mar 1998
Hallas C, Greiner A, Peters K, Müller-Hermelink H K
Abstract excerpt
High-grade mucosa-associated lymphoid tissue (MALT) B-cell lymphoma of the stomach shares several features with its low-grade counterpart. The latter is nearly invariably associated with Helicobacter pylori, and the tumor cells of all MALT lymphomas normally express surface antigen receptors; thu...
Topics
- Amino Acid Sequence
- Antibody Affinity
- Antigens, Neoplasm
- Base Sequence
- Burkitt Lymphoma
- Genetic Variation
- Germ-Line Mutation
- Humans
- Immunoglobulin Variable Region
- Lymphoma, B-Cell, Marginal Zone
- Molecular Sequence Data
- Mutation
- Stomach Neoplasms