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Article

Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas.

Blood - 1 May 1997

Bahler D W, Miklos J A, Swerdlow S H

Abstract excerpt

Salivary gland mucosa-associated lymphoid tissue (MALT) type lymphomas are typically indolent B-cell neoplasms that are often associated with Sjogren's syndrome. To better define the cell of origin and evaluate whether antigen receptor stimulation may be playing a role in tumor growth, the Ig heavy and light chain variable genes (VH and VL) expressed by five salivary gland MALT lymphomas were cloned and...

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Source

Identifiers

PMID: 9129040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas.PMID 9129040Read ↗

Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin VH genes show frequent use of V1-69 with distinctive CDR3 featuresSemantic proximity Read ↗

Somatic hypermutation in low-grade mucosa-associated lymphoid tissue- type B-cell lymphomaSemantic proximity Read ↗

Immunoglobulin VH genes of high-grade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen-dependent affinity maturation.Semantic proximity Read ↗

VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.Semantic proximity Read ↗

Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion.Semantic proximity Read ↗

Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin heavy chain variable region genes in thymic marginal zone B-cell lymphoma of MALT type of a patient with Sjögren's syndrome.Semantic proximity Read ↗

Use of similar immunoglobulin VH gene segments by MALT lymphomas of the ocular adnexa.Semantic proximity Read ↗

Clonal Salivary Gland Infiltrates Associated With Myoepithelial Sialadenitis (Sjogren's Syndrome) Begin as Nonmalignant Antigen-Selected ExpansionsSemantic proximity Read ↗

Characterization of genetic events involving IgH switch regions in gastric low-grade MALT lymphomas and B-CLLSemantic proximity Read ↗

Ongoing immunoglobulin gene mutations in mantle cell lymphomas.Semantic proximity Read ↗

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.Semantic proximity Read ↗

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