Article
Primary diffuse large B cell lymphoma of the stomach: analysis of somatic mutations in the rearranged immunoglobulin heavy chain variable genes indicates antigen selection.
Leukemia - 1 Jul 1999
Driessen A, Tierens A, Ectors N, Stul M, Pittaluga S, Geboes K, Delabie J, De Wolf-Peeters C
Abstract excerpt
Gastric low grade MALT lymphomas show a pattern of somatic mutations in their rearranged immunoglobulin genes, indicative of antigen selection. This provides evidence for antigen stimulation in the lymphomagenesis. Gastric diffuse large B cell lymphomas develop secondary to low grade MALT lymphoma or de novo. To study whether antigen-selection is also a feature of primary diffuse large B cell lymphomas, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.