Article
Low-grade pulmonary mucosa-associated lymphoid tissue lymphoma with or without intraclonal variation.
American journal of respiratory and critical care medicine - 1 Nov 1998
Kurosu K, Yumoto N, Furukawa M, Kuriyama T, Mikata A
Abstract excerpt
We examined the immunoglobulin heavy chain variable (Ig VH) region genes of 11 low-grade pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas by a two-step polymerase chain reaction (PCR) and sequencing analysis. We observed frequent somatic mutations with the positive selective pressure of the rearranged Ig VH genes in all cases, indicative of postgerminal center cell origin. Eight cases demonstrated...
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