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Article

Treatment of murine lupus with cDNA encoding IFN-gammaR/Fc.

The Journal of clinical investigation - 1 Jul 2000

Lawson B R, Prud'homme G J, Chang Y, Gardner H A, Kuan J, Kono D H, Theofilopoulos A N

Abstract excerpt

IFN-gamma, a pleiotropic cytokine, is a key effector molecule in the pathogenesis of several autoimmune diseases, including lupus. Importantly, deletion of IFN-gamma or IFN-gammaR in several lupus-predisposed mouse strains resulted in significant disease reduction, suggesting the potential for therapeutic intervention. We evaluated whether intramuscular injections of plasmids with cDNA encoding IFN-gammaR/Fc can...

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Identifiers

PMID: 10903336
DOI: 10.1172/JCI10167
PMCID: PMC314313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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