Article
Intrinsic defects in macrophage IL-12 production associated with immune dysfunction in the MRL/++ and New Zealand Black/White F1 lupus-prone mice and the Leishmania major-susceptible BALB/c strain.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1998
Alleva D G, Kaser S B, Beller D I
Abstract excerpt
We have demonstrated that macrophages (Mphi) from young, prediseased, lupus-prone MRL/++ and New Zealand Black/White F1 mice display defective production of TNF-alpha, IL-1, and IL-6, but normal production of IL-10. In an attempt to determine the potential functional implications of this phenotyp...
Topics
- Animals
- Autoimmune Diseases
- Autoimmunity
- Cells, Cultured
- Crosses, Genetic
- Culture Media, Conditioned
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Interferon-gamma
- Interleukin-1
- Interleukin-10
- Interleukin-12
- Interleukin-6
- Leishmania major