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Article

Type-I Interferon Receptor Deficiency Reduces Lupus-like Disease in NZB Mice

17 Mar 2003

Abstract excerpt

Indirect evidence suggests that type-I interferons (IFN-alpha/beta) play a significant role in the pathogenesis of lupus. To directly examine the contribution of these pleiotropic molecules, we created congenic NZB mice lacking the alpha-chain of IFN-alpha/betaR, the common receptor for the multiple IFN-alpha/beta species. Compared with littermate controls, homozygous IFN-alpha/betaR-deleted NZB mice had...

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Identifiers

PMID: 12642605
DOI: 10.1084/jem.20021996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Type-I Interferon Receptor Deficiency Reduces Lupus-like Disease in NZB MicePMID 12642605Read ↗

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