Article
Role of Csk in neural differentiation of the embryonic carcinoma cell line P19.
FEBS letters - 7 Apr 1997
Takayama Y, Nada S, Nagai K, Okada M
Abstract excerpt
To examine the neural function of Csk (C-terminal Src kinase), a membrane-targeted form of Csk (Src/Csk) and its kinase-defective variant (DK-Src/Csk) were expressed in the embryonic carcinoma cell line P19. Expression of Src/Csk, but not DK-Src/Csk, caused reduction of the specific activities of Src and Fyn in the differentiated P19 cells. During neural differentiation, the specific activity of Src was elevated...
Topics
- Animals
- CSK Tyrosine-Protein Kinase
- Carcinoma, Embryonal
- Cell Differentiation
- Leukocyte L1 Antigen Complex
- Mice
- Neural Cell Adhesion Molecules
- Neurons
- Phenotype
- Protein-Tyrosine Kinases
- Tumor Cells, Cultured