Article
Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading.
Molecular and cellular biology - 1 Feb 1995
Bergman M, Joukov V, Virtanen I, Alitalo K
Abstract excerpt
The C-terminal Src kinase p50csk phosphorylates Src family tyrosine kinases and down-regulates their activity in vitro. To gain insight into the cellular functions of this potentially antioncogenic enzyme, we have overexpressed the csk cDNA by using an inducible promoter in HeLa cells. Despite so...
Topics
- CSK Tyrosine-Protein Kinase
- Cell Adhesion
- Cell Adhesion Molecules
- Cytoskeletal Proteins
- Focal Adhesion Kinase 1
- Focal Adhesion Protein-Tyrosine Kinases
- Gene Expression
- Gene Expression Regulation
- HeLa Cells
- Humans
- Integrins
- Kinetics
- Paxillin
- Phenotype
- Phosphoproteins