Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells.

doi:10.1111/j.1471-4159.2007.05121.x

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Article

Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells.

Journal of neurochemistry - 1 Apr 2008

Mitsuhashi Hiroaki, Futai Eugene, Sasagawa Noboru, Hayashi Yukiko, Nishino Ichizo, Ishiura Shoichi

Abstract excerpt

SHPS-1 is an immunoglobulin superfamily protein with four immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic region. Various neurotrophic factors induce the tyrosine phosphorylation of SHPS-1 and the association of SHPS-1 with the protein tyrosine phosphatase SHP-2. Using a yeast two-hybrid screen, we identified a protein tyrosine kinase, Csk-homologous kinase (CHK), as an...

Topics

Animals
Bacterial Proteins
Cells, Cultured
Cerebral Cortex
Chlorocebus aethiops
Cloning, Molecular
Embryo, Mammalian
Gene Expression
Glutathione Transferase
Humans
Luminescent Proteins
Mutation
Neurites
Neurons
PC12 Cells

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Open in PubMed

Identifiers

PMID: 17999719
DOI: 10.1111/j.1471-4159.2007.05121.x

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Phosphorylation

Proto-Oncogene Proteins pp60(c-src)

Rats