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Article

Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.

Science signaling - 13 Oct 2009

Meyn Malcolm A, Smithgall Thomas E

Abstract excerpt

Multiple Src family kinases (SFKs) are present in murine embryonic stem (mES) cells. Whereas complete inhibition of SFK activity blocks mES cell differentiation, sole inhibition of the SFK member c-Yes induces differentiation. Thus, individual SFKs may have opposing roles in the regulation of mES cell fate. To test this possibility, we generated SFK mutants with engineered resistance to a nonselective SFK...

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Identifiers

PMID: 19825829
DOI: 10.1126/scisignal.2000311
PMCID: PMC2775445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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