Article
Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997
Kawakami Y, Miura T, Bissonnette R, Hata D, Khan W N, Kitamura T, Maeda-Yamamoto M, Hartman S E, Yao L, Alt F W, Kawakami T
Abstract excerpt
Mast cells derived from Bruton's tyrosine kinase (Btk)-defective xid or btk null mice showed greater expansion in culture containing interleukin-3 (IL-3) than those from wild-type (wt) mice. Although the proliferative response to IL-3 was not significantly different between the wt and xid mast cells, xid and btk null mast cells died by apoptosis more slowly than their wt counterparts upon IL-3 deprivation....
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