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Article

Enhanced Expression of Bruton's Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2016

Corneth Odilia B J, de Bruijn Marjolein J W, Rip Jasper, Asmawidjaja Patrick S, Kil Laurens P, Hendriks Rudi W

Abstract excerpt

Upon BCR stimulation, naive B cells increase protein levels of the key downstream signaling molecule Bruton's tyrosine kinase (BTK). Transgenic CD19-hBtk mice with B cell-specific BTK overexpression show spontaneous germinal center formation, anti-nuclear autoantibodies, and systemic autoimmunity resembling lupus and Sjögren syndrome. However, it remains unknown how T cells are engaged in this pathology. In this...

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Share to Agammaglobulinaemia Tyrosine Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27226091
DOI: 10.4049/jimmunol.1600208

Genes

BTK
BCR
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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