Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism of murine Fas ligand that affects the biological activity.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997

Kayagaki N, Yamaguchi N, Nagao F, Matsuo S, Maeda H, Okumura K, Yagita H

Abstract excerpt

Fas ligand (FasL) is a member of the tumor necrosis factor family and induces apoptosis in Fas (CD95)-bearing target cells. In this study, we generated several mAbs that react with mouse FasL (mFasL) and characterized their functional properties. One of these mAbs, K10, specifically reacted with mFasL derived from C57BL/6 (B6) mice, but not that from BALB/c mice as estimated by surface staining and blocking of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fas Ligand Protein

Share to Membrane Glycoproteins

Share to Molecular Sequence Data

Share to Polymorphism, Genetic

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 9108079
DOI: 10.1073/pnas.94.8.3914
PMCID: PMC20542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism of murine Fas ligand that affects the biological activity.PMID 9108079Read ↗

A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas.Semantic proximity Read ↗

Modulation of the Fas-apoptosis-signalling pathway by functional polymorphisms at Fas, FasL and Fadd and their implication in T-cell lymphoblastic lymphoma susceptibility.Semantic proximity Read ↗

Biology of FasL.Semantic proximity Read ↗

Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease.Semantic proximity Read ↗

Functional Fas (Cd95/Apo-1) promoter polymorphisms in inbred mouse strains exhibiting different susceptibility to gamma-radiation-induced thymic lymphoma.Semantic proximity Read ↗

MRL Strains Have a BAFFR Mutation without Functional Consequence.Semantic proximity Read ↗

Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo.Semantic proximity Read ↗

The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.Semantic proximity Read ↗

Fas-deficient lpr mice are more susceptible to graft-versus-host disease.Semantic proximity Read ↗

Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice.Semantic proximity Read ↗

A new alternative splice variant of the mouse Fas antigen with a deletion in the N-terminal portion of the extracellular domain.Semantic proximity Read ↗

Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.