Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice.

European journal of immunology - 1 Mar 2002

Choi Youngnim, Simon-Stoos Karen, Puck Jennifer M

Abstract excerpt

Apoptosis of activated lymphocytes is crucial to the maintenance of immune homeostasis and self-tolerance, as demonstrated by the well-known autoimmune MRL lpr mouse lacking the death receptor Fas. However, even MRL+/+ activated T cells have a resistance to Fas-mediated apoptosis as compared to T cells from the non-autoimmune FVB/N strain. To understand the molecular mechanisms underlying these strain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-X Protein
Share to Caspase 3
Share to Concanavalin A

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Induction

Share to Enzyme Precursors

Share to fas Receptor

Share to Mice, Inbred MRL lpr

Share to Receptors, Interleukin-2

Source

Identifiers

PMID: 11857342
DOI: 10.1002/1521-4141(200203)32:3<677::AID-IMMU677>3.0.CO;2-I

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice.PMID 11857342Read ↗

The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice.Semantic proximity Read ↗

Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice.Semantic proximity Read ↗

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.Semantic proximity Read ↗

Cytokine Dysregulation Induced by Apoptotic Cells Is a Shared Characteristic of Murine LupusSemantic proximity Read ↗

Role of defective apoptosis in type 1 diabetes and other autoimmune diseases.Semantic proximity Read ↗

Immunological and pathological consequences of mutations in both Fas and Fas ligand.Semantic proximity Read ↗

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.Semantic proximity Read ↗

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.Semantic proximity Read ↗

Combining Fas mutation with interleukin-2 deficiency prevents Colitis and Lupus: implicating interleukin-2 for auto-reactive T cell expansion and Fas ligand for colon epithelial cell death.Semantic proximity Read ↗

MRL Strains Have a BAFFR Mutation without Functional Consequence.Semantic proximity Read ↗

Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation.Semantic proximity Read ↗

Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.