Article
MRL Strains Have a BAFFR Mutation without Functional Consequence.
PloS one - 1 Jan 2016
Allman Windy R, Liu Lunhua, Coleman Adam S, Akkoyunlu Mustafa
Abstract excerpt
It has been shown that B cell activating factor receptor (BAFFR) is critical for B cell development and survival. In this study, we sought to evaluate the expression and function of BAFFR across multiple stains of mice that vary in their potential to develop systemic autoimmune disease. The inability of a commercial antibody to bind to BAFFR in the autoimmune prone mouse strains, MRL and MRL/Lpr led to the...
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