Article
Development of T cells in SCID mice grafted with fetal thymus from AKR mice or F344 rats.
European journal of immunology - 1 Dec 1993
Maeda K, Nagasawa H, Furukawa A, Hisaeda H, Maekawa Y, Manabe T, Kudo E, Good R A, Himeno K
Abstract excerpt
To examine the development of T cells within an allogeneic or xenogeneic environment, we engrafted the fetal thymus from AKR mice or F344 rats under the kidney capsule of SCID mice (mTG and rTG mice). T lymphopoiesis developed in SCID mice 2 months after transplantation, although the ratio of CD4/CD8 in both experimental groups was different from that of normal control. T cells in mTG mice did not show in vitro...
Topics
- Animals
- Clonal Deletion
- Graft vs Host Disease
- Hematopoiesis
- Lymphocyte Activation
- Mice
- Mice, Inbred AKR
- Mice, Inbred C57BL
- Mice, SCID
- Phenotype
- Rats