CD8+ T cells induce medullary thymic epithelium and CD4+CD8+CD25+ TCRbeta- thymocytes in SCID mice.

doi:10.1046/j.1365-3083.2001.00983.x

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Article

CD8+ T cells induce medullary thymic epithelium and CD4+CD8+CD25+ TCRbeta- thymocytes in SCID mice.

Scandinavian journal of immunology - 1 Nov 2001

Pettersson F E, Schneider M K, Andersson J, Grönvik K O

Abstract excerpt

During T-cell development the transition in the thymus of CD4-CD8- double negative (DN) progenitor T cells into CD4+CD8+ double positive (DP) cells is dependent on the expression of a T-cell receptor (TCR)-beta-chain protein. In this study purified peripheral CD4+ and CD8+ T lymphocytes from the C.B-17 strain of mice were adoptively transferred into syngeneic, neonatal SCID mice, where donor cells resided at...

Topics

Adoptive Transfer
Animals
Animals, Newborn
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Movement
Epithelium
Lymphocyte Activation
Mice
Mice, SCID
Phenotype
T-Lymphocyte Subsets
Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 11696203
DOI: 10.1046/j.1365-3083.2001.00983.x

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