Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.

Abstract excerpt

The autosomal recessive scid mutation results in defective immunoglobulin and T cell receptor gene rearrangement. The scid mutation occurred in the allotype congenic C.B-17 line, and up to 25% of C.B-17 scid mice spontaneously produce both T cells and immunoglobulin, a phenotype known as "leaky."...

Topics

• Animals
• Animals, Newborn
• B-Lymphocytes
• Genes, Immunoglobulin
• Homozygote
• Immunoglobulin M
• Mice
• Mice, Inbred BALB C
• Mice, SCID
• Mutation
• T-Lymphocytes