Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells.

doi:10.1084/jem.185.7.1337

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Article

Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells.

The Journal of experimental medicine - 7 Apr 1997

Darley R L, Hoy T G, Baines P, Padua R A, Burnett A K

Abstract excerpt

RAS mutations arise at high frequency (20-40%) in both acute myeloid leukemia and myelodysplastic syndrome (which is considered to be a manifestation of preleukemic disease). In each case, mutations arise predominantly at the N-RAS locus. These observations suggest a fundamental role for this onc...

Topics

Acute Disease
Antigens, CD34
Apoptosis
Cell Differentiation
Erythroid Precursor Cells
Erythropoiesis
Erythropoietin
Genes, Reporter
Genes, ras
Humans
Leukemia, Myeloid
Mutation
Myelodysplastic Syndromes
Preleukemia

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