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Article

Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells.

The Journal of experimental medicine - 7 Apr 1997

Darley R L, Hoy T G, Baines P, Padua R A, Burnett A K

Abstract excerpt

RAS mutations arise at high frequency (20-40%) in both acute myeloid leukemia and myelodysplastic syndrome (which is considered to be a manifestation of preleukemic disease). In each case, mutations arise predominantly at the N-RAS locus. These observations suggest a fundamental role for this oncogene in leukemogenesis. However, despite its obvious significance, little is known of how this key oncogene may...

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Source

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Identifiers

PMID: 9104820
DOI: 10.1084/jem.185.7.1337
PMCID: PMC2196261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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