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Article

Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras.

Molecular and cellular biology - 1 May 2006

Omidvar Nader, Pearn Lorna, Burnett Alan K, Darley Richard L

Abstract excerpt

Hyperactivation of Ras is one of the most common abnormalities in acute myeloid leukemia. In experimental models, Ras inhibits myeloid differentiation, which is characteristic of leukemia; however, the mechanism through which it disrupts hematopoiesis is poorly understood. In multipotent FDCP-mix cells, Ras inhibits terminal neutrophil differentiation, thereby indefinitely extending their proliferative potential....

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Identifiers

PMID: 16648489
DOI: 10.1128/MCB.26.10.3966-3975.2006
PMCID: PMC1489015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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