Article
Mutant RAS inhibits neutrophil but not macrophage differentiation and allows continued growth of neutrophil precursors.
Experimental hematology - 1 Nov 1999
Darley R L, Burnett A K
Abstract excerpt
Mutational activation of RAS is the most common molecular abnormality in myeloid leukemias. In order to better understand its role in leukemogenesis, we have devised a model based on the multipotent cell line, FDCP-mix. We show that expression of mutant RAS in FDCP-mix strongly inhibits terminal neutrophil differentiation under the influence of G-CSF plus GM-CSF at the metamyelocyte stage, whereas macrophage...
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