Article
Protein kinase C mediates mutant N-Ras-induced developmental abnormalities in normal human erythroid cells.
Blood - 1 Dec 2002
Darley Richard L, Pearn Lorna, Omidvar Nader, Sweeney Marion, Fisher Janet, Phillips Sarah, Hoy Terry, Burnett Alan K
Abstract excerpt
RAS mutations are one of the most frequent molecular abnormalities associated with myeloid leukemia and preleukemia, yet there is a poor understanding of how they contribute to the pathogenesis of these conditions. Here, we describe the consequences of ectopic mutant N-Ras (N-Ras*) expression on normal human erythropoiesis. We show that during early (erythropoietin [EPO]-independent) erythropoiesis, N-Ras*...
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