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Article

Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.

Blood - 15 Sept 2006

Braun Benjamin S, Archard Joehleen A, Van Ziffle Jessica A G, Tuveson David A, Jacks Tyler E, Shannon Kevin

Abstract excerpt

Somatic activation of a conditional targeted Kras(G12D) allele induces a fatal myeloproliferative disease in mice that closely models juvenile and chronic myelomonocytic leukemia. These mice consistently develop severe and progressive anemia despite adequate numbers of clonogenic erythroid progenitors in the bone marrow and expanded splenic hematopoiesis. Ineffective erythropoiesis is characterized by impaired...

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Identifiers

PMID: 16720837
DOI: 10.1182/blood-2006-01-013490
PMCID: PMC1895533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.PMID 16720837Read ↗

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