Elf-1 contributes to the function of the complex interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor alpha gene.

doi:10.1084/jem.185.7.1211

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Article

Elf-1 contributes to the function of the complex interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor alpha gene.

The Journal of experimental medicine - 7 Apr 1997

Serdobova I, Pla M, Reichenbach P, Sperisen P, Ghysdael J, Wilson A, Freeman J, Nabholz M

Abstract excerpt

Lymphocytes regulate their responsiveness to IL-2 through the transcriptional control of the IL-2R alpha gene, which encodes a component of the high affinity IL-2 receptor. In the mouse IL-2R alpha gene this control is exerted via two regulatable elements, a promoter proximal region, and an IL-2-...

Topics

Animals
Base Sequence
Binding Sites
DNA-Binding Proteins
Enhancer Elements, Genetic
Ephrin-A2
Interleukin-2
Mice
Molecular Sequence Data
Mutation
Nuclear Proteins
Protein Binding
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ets

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Interleukin-2

T-Lymphocytes

Transcription Factors

Tumor Cells, Cultured

Source

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Identifiers

PMID: 9104808
DOI: 10.1084/jem.185.7.1211
PMCID: PMC2196269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9104808-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.