Article
Analysis of the AP-1 sites in the IL-2 promoter.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1992
Jain J, Valge-Archer V E, Rao A
Abstract excerpt
We have investigated the role of the two AP-1 sites, located at approximately -150 and -180 bp relative to the transcription start site, in induction of the IL-2 promoter through the TCR/CD3 complex. We show that only the proximal (-150 bp) AP-1 site is functional in vitro, as judged by its ability to bind nuclear proteins from T cells stimulated with Ag or anti-CD3 epsilon. The inducible nuclear proteins binding...
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