Analysis of the AP-1 sites in the IL-2 promoter.

Article

Analysis of the AP-1 sites in the IL-2 promoter.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1992

Jain J, Valge-Archer V E, Rao A

Abstract excerpt

We have investigated the role of the two AP-1 sites, located at approximately -150 and -180 bp relative to the transcription start site, in induction of the IL-2 promoter through the TCR/CD3 complex. We show that only the proximal (-150 bp) AP-1 site is functional in vitro, as judged by its abili...

Topics

Animals
Base Sequence
Gene Expression Regulation
Genes, fos
Genes, jun
Interleukin-2
Mice
Molecular Sequence Data
Mutation
Promoter Regions, Genetic
Proto-Oncogene Proteins c-jun
RNA, Messenger
Transfection

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.