The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells.

doi:10.1101/gad.7.12a.2418

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Article

The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells.

Genes & development - 1 Dec 1993

Carlsson P, Waterman M L, Jones K A

Abstract excerpt

hLEF/TCF-1 alpha is a lymphoid cell-specific HMG protein that activates the distal enhancer of the gene encoding the alpha-subunit of the T-cell receptor (TCR alpha). We have shown previously that transcriptional activation by hLEF is highly dependent on the context of its binding site within the...

Topics

Amino Acid Sequence
Base Sequence
Cells, Cultured
DNA-Binding Proteins
Enhancer Elements, Genetic
High Mobility Group Proteins
Lymphoid Enhancer-Binding Factor 1
Molecular Sequence Data
Mutation
Receptors, Antigen, T-Cell, alpha-beta
Recombinant Fusion Proteins
Trans-Activators
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 8253387
DOI: 10.1101/gad.7.12a.2418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8253387-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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