Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells.

Genes & development - 1 Dec 1993

Carlsson P, Waterman M L, Jones K A

Abstract excerpt

hLEF/TCF-1 alpha is a lymphoid cell-specific HMG protein that activates the distal enhancer of the gene encoding the alpha-subunit of the T-cell receptor (TCR alpha). We have shown previously that transcriptional activation by hLEF is highly dependent on the context of its binding site within the TCR alpha enhancer. Here, we demonstrate that hLEF contains a potent transcriptional activation domain that is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to Recombinant Fusion Proteins

Share to Transcription Factors

Source

Identifiers

PMID: 8253387
DOI: 10.1101/gad.7.12a.2418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells.PMID 8253387Read ↗

A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.Semantic proximity Read ↗

An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro.Semantic proximity Read ↗

Regulation of the human T-cell receptor alpha gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements.Semantic proximity Read ↗

A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.Semantic proximity Read ↗

ALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancer.Semantic proximity Read ↗

Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cellsSemantic proximity Read ↗

HTLV-1 Viral Factor HBZ Induces CCR4 to Promote T-cell Migration and ProliferationSemantic proximity Read ↗

The role of viral enhancer "core" motif-related sequences in regulating T cell receptor-gamma and -delta gene expression.Semantic proximity Read ↗

Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expressionSemantic proximity Read ↗

Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.Semantic proximity Read ↗

Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins.Semantic proximity Read ↗

Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.