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Article

Identification of two novel palindromic regulatory elements in the murine interleukin-5 promoter.

Molecular immunology - 1 Feb 1998

Schwenger G T, Mordvinov V A, Karlen S, D'Ercole M, Sanderson C J

Abstract excerpt

Interleukin-5 has remarkable specificity for the eosinophil lineage. This fact, combined with the biological specificity of eosinophilia suggests tight and independent regulation of IL-5 expression. Here we report two novel palindromic regulatory elements (PRE) which contain positive regulatory motifs (PRM) that control transcription of the murine IL-5 gene. The first element, mPRE1-IL5 (-79 to -90) contains the...

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PMID: 9694515
DOI: 10.1016/s0161-5890(98)00023-6

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