Article
The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.
Science (New York, N.Y.) - 18 Apr 1997
Kaisho T, Schwenk F, Rajewsky K
Abstract excerpt
In antibody responses, B cells switch from the expression of immunoglobulin (Ig) mu and delta heavy (H) chains to that of other Ig classes (alpha, gamma, or epsilon), each with a distinct effector function. Membrane-bound forms of alpha, gamma, and epsilon, but not mu and delta, have highly conse...
Topics
- Animals
- B-Lymphocytes
- Cytoplasm
- Gene Targeting
- Immunization
- Immunoglobulin Class Switching
- Immunoglobulin G
- Immunoglobulin gamma-Chains
- Immunologic Memory
- Mice
- Mutation
- Receptors, Antigen, B-Cell