Article
The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.
Science (New York, N.Y.) - 18 Apr 1997
Kaisho T, Schwenk F, Rajewsky K
Abstract excerpt
In antibody responses, B cells switch from the expression of immunoglobulin (Ig) mu and delta heavy (H) chains to that of other Ig classes (alpha, gamma, or epsilon), each with a distinct effector function. Membrane-bound forms of alpha, gamma, and epsilon, but not mu and delta, have highly conserved cytoplasmic tails. Mutant mice unable to express membrane gamma1 H chains or producing tailless gamma1 H chains...
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