Article
Effect of transmembrane and cytoplasmic domains of IgE on the IgE response.
Science (New York, N.Y.) - 18 Apr 1997
Achatz G, Nitschke L, Lamers M C
Abstract excerpt
B cells use immunoglobulin M (IgM) and IgD as antigen receptors, but after contact with antigen they can switch and use IgG, IgA, or IgE. In mice lacking the transmembrane and cytoplasmic domains of IgE, serum IgE is reduced by more than 95 percent and, after immunization, specific responses are...
Topics
- Animals
- Antibody-Producing Cells
- Antigen Presentation
- Cytoplasm
- Dimerization
- Female
- Gene Targeting
- Immunization
- Immunoglobulin Class Switching
- Immunoglobulin E
- Immunoglobulin G
- Immunologic Memory
- Male
- Mice
- Mutation
- Nippostrongylus
- Receptors, Antigen, B-Cell
- Signal Transduction