Article
A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen.
Molecular biology of the cell - 1 Dec 2003
Rajasekaran Sigrid A, Anilkumar Gopalakrishnapillai, Oshima Eri, Bowie James U, Liu He, Heston Warren, Bander Neil H, Rajasekaran Ayyappan K
Abstract excerpt
Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed at high levels in prostate cancer and in tumor-associated neovasculature. In this study, we report that PSMA is internalized via a clathrin-dependent endocytic mechanism and that internalization of PSMA is mediated by the five N-terminal amino acids (MWNLL) present in its cytoplasmic tail. Deletion of the cytoplasmic tail abolished...
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