Identification of a cytoplasmic signal for apical transcytosis.

doi:10.1111/j.1600-0854.2009.00941.x

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Article

Identification of a cytoplasmic signal for apical transcytosis.

Traffic (Copenhagen, Denmark) - 1 Aug 2009

Luton Frédéric, Hexham Mark J, Zhang Min, Mostov Keith E

Abstract excerpt

Polarized epithelial cells contain apical and basolateral surfaces with distinct protein compositions. To establish and maintain this asymmetry, newly made plasma membrane proteins are sorted in the trans Golgi network for delivery to apical or basolateral surfaces. Signals for basolateral sorting are generally located in the cytoplasmic domain of the protein, whereas signals for apical sorting can be in any part...

Topics

Amino Acid Sequence
Animals
Cell Line
Cell Polarity
Cytoplasm
Endocytosis
Epithelial Cells
Exocytosis
Glycosylation
Humans
Molecular Sequence Data
Mutation
Protein Sorting Signals
Protein Transport
Receptors, Polymeric Immunoglobulin
Signal Transduction

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Identifiers

PMID: 19522755
DOI: 10.1111/j.1600-0854.2009.00941.x
PMCID: PMC2920487

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