Article
Identification of a cytoplasmic signal for apical transcytosis.
Traffic (Copenhagen, Denmark) - 1 Aug 2009
Luton Frédéric, Hexham Mark J, Zhang Min, Mostov Keith E
Abstract excerpt
Polarized epithelial cells contain apical and basolateral surfaces with distinct protein compositions. To establish and maintain this asymmetry, newly made plasma membrane proteins are sorted in the trans Golgi network for delivery to apical or basolateral surfaces. Signals for basolateral sorting are generally located in the cytoplasmic domain of the protein, whereas signals for apical sorting can be in any part...
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