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Article

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1 Apr 1997

Abstract excerpt

Recent epidemiologic studies have shown a 40-50% reduction in mortality from colorectal cancer in individuals who take nonsteroidal antiinflammatory drugs on a regular basis compared with those not taking these agents. One property shared by all of these drugs is their ability to inhibit cyclooxygenase (COX), a key enzyme in the conversion of arachidonic acid to prostaglandins. Two isoforms of COX have been...

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Identifiers

PMID: 9096394
DOI: 10.1073/pnas.94.7.3336

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