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Article

Targeting cyclooxygenase‐2 for prevention and therapy of colorectal cancer

10 May 2006

Abstract excerpt

Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A causal link for COX-2 in epithelial tumorigenesis was shown in genetically manipulated animal models of colon and breast carcinoma. Studies have elucidated the regulation of COX-2 expression and have identified EP receptors through which...

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PMID: 16688727
DOI: 10.1002/mc.20232

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