Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications.

Frontiers in bioscience : a journal and virtual library - 1 Sept 2004

Chu Arthur J, Chou Ta-Hsu, Chen Ben D

Abstract excerpt

Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in pre-neoplastic tissues and several human cancers including colorectal cancer. Evidence linking COX-2 activity to carcinogenesis was derived from epidemiologic studies and animal models with defect adenomatous polyposis coli (APC) gene. PGE2 induced by COX-2 exerts several biological properties that may be advantageous for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Anti-Inflammatory Agents, Non-Steroidal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2

Share to Cyclooxygenase Inhibitors

Share to Genes, APC

Share to Neovascularization, Pathologic

Share to Prostaglandins

Share to Pyrazoles

Source

Identifiers

PMID: 15353307
DOI: 10.2741/1429

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications.PMID 15353307Read ↗

Targeting cyclooxygenase‐2 for prevention and therapy of colorectal cancerSemantic proximity Read ↗

Cyclooxygenase-2: a novel target for cancer chemotherapy?Semantic proximity Read ↗

The role of COX-2 in intestinal cancer.Semantic proximity Read ↗

Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal CancerSemantic proximity Read ↗

The molecular basis for prevention of colorectal cancer.Semantic proximity Read ↗

[Cyclooxygenase 2 and carcinogenesis].Semantic proximity Read ↗

COX Selectivity and Animal Models for Colon CancerSemantic proximity Read ↗

Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesisSemantic proximity Read ↗

The -765C allele of the cyclooxygenase-2 gene as a potential risk factor of colorectal cancer: a meta-analysis.Semantic proximity Read ↗

Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical SignificanceSemantic proximity Read ↗

Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies.Semantic proximity Read ↗

Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin–proteasome system and Cox‐2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.