Article
[Cyclooxygenase 2 and carcinogenesis].
Bulletin du cancer - 1 May 2004
Rodrigues Sylvie, Bruyneel Erik, Rodrigue Christelle M, Shahin Emami, Gespach Christian
Abstract excerpt
The membrane glycoprotein Cox2 is regulated at transcriptional and post-transcriptional levels by pro-inflammatory agents, cytokines, growth factors, oncogenes, and tumor-promoters. Cox2 is expressed during early stages of colorectal carcinogenesis from the premalignant adenoma stage, and adenocarcinomas of stomach, colon, breast, lung and prostate. Its expression is detected in neoplastic, inflammatory,...
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