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Article

Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers.

Yonsei medical journal - 30 Jun 2007

Lim Sung-Chul, Lee Tae-Beum, Choi Cheol-Hee, Ryu So-Yeon, Kim Kyung-Jong, Min Young-Don

Abstract excerpt

PURPOSE: Cyclooxygenase (COX)-2 is an inducible isoform responsive to cytokines, mitogens, and growth factors, and is believed to be an important enzyme related to colorectal cancer (CRC). Existing evidence suggests that COX-2 expression is normally suppressed by wild-type p53 but not mutant p53, suggesting that loss of p53 function may result in the induction of COX-2 expression. The aim of this study was to...

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Source

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Identifiers

PMID: 17594159
DOI: 10.3349/ymj.2007.48.3.495
PMCID: PMC2628091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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