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Article

Differential expression of cyclooxygenase 2 in human colorectal cancer

1 Nov 1999

Abstract excerpt

BACKGROUND: Experimental, clinical, and epidemiological studies have implicated mitogenic metabolites of arachidonic acid such as prostaglandin E(2) (PGE(2)) in colorectal carcinogenesis. Recently, cyclooxygenase 2 (COX-2) which catalyses the conversion of arachidonic acid to PGE(2), has displayed increased levels in human colorectal cancer. AIMS: To evaluate whether there is differential COX-2 expression from...

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PMID: 10517910
DOI: 10.1136/gut.45.5.730

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