Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclooxygenase-2: a novel target for cancer chemotherapy?

Journal of cancer research and clinical oncology - 1 Jul 2001

Dempke W, Rie C, Grothey A, Schmoll H J

Abstract excerpt

Epidemiologic studies have documented a 40-50% reduction in incidence of colorectal cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs are known to inhibit cyclooxygenases (COX-1, COX-2), the basic mechanism of their antitumor effects is conceivably the altered metabolism of arachidonic acid and, subsequently, prostaglandins (PGs). Although COX-2, the inducible isoform, is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticarcinogenic Agents
Share to Endothelial Growth Factors
Share to Fibroblast Growth Factor 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunosuppression Therapy

Share to Lymphokines

Share to Platelet-Derived Growth Factor

Share to Prostaglandin-Endoperoxide Synthases

Share to Vascular Endothelial Growth Factors

Source

Identifiers

PMID: 11469677
DOI: 10.1007/s004320000225

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclooxygenase-2: a novel target for cancer chemotherapy?PMID 11469677Read ↗

Targeting cyclooxygenase‐2 for prevention and therapy of colorectal cancerSemantic proximity Read ↗

Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications.Semantic proximity Read ↗

Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal CancerSemantic proximity Read ↗

The role of COX-2 in intestinal cancer.Semantic proximity Read ↗

[Cyclooxygenase 2 and carcinogenesis].Semantic proximity Read ↗

Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesisSemantic proximity Read ↗

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potentialSemantic proximity Read ↗

Cyclooxygenase-2: potential role in regulation of drug efflux and multidrug resistance phenotype.Semantic proximity Read ↗

Differential expression of cyclooxygenase 2 in human colorectal cancerSemantic proximity Read ↗

Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin–proteasome system and Cox‐2Semantic proximity Read ↗

Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis.Semantic proximity Read ↗

Growth inhibitory effect of celecoxib and rofecoxib on human colorectal carcinoma cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.