Article
Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD.
Cell - 4 Apr 1997
Tajbakhsh S, Rocancourt D, Cossu G, Buckingham M
Abstract excerpt
We analyzed Pax-3 (splotch), Myf-5 (targeted with nlacZ), and splotch/Myf-5 homozygous mutant mice to investigate the roles that these genes play in programming skeletal myogenesis. In splotch and Myf-5 homozygous embryos, myogenic progenitor cell perturbations and early muscle defects are distin...
Topics
- Animals
- Cell Movement
- Cells, Cultured
- DNA-Binding Proteins
- Embryo, Mammalian
- Female
- Fluorescent Antibody Technique
- Gene Expression Regulation, Developmental
- Homozygote
- Male
- Mesoderm
- Mice
- Mice, Mutant Strains
- Muscle Proteins
- Muscle, Skeletal
- Mutation
- MyoD Protein
- Myogenic Regulatory Factor 5