Article
The Splotch mutation interferes with muscle development in the limbs.
Anatomy and embryology - 1 Feb 1993
Franz T, Kothary R, Surani M A, Halata Z, Grim M
Abstract excerpt
Homozygosity for the Splotch mutation causes neural tube and neural crest defects in mice. It has been demonstrated that Splotch mutant mice carry mutations in the homeodomain of the Pax-3 gene. Pax-3 is expressed in the neural tube, some neural crest derivatives, the mesenchyme of the limb bud a...
Topics
- Animals
- Embryonic and Fetal Development
- Extremities
- Homozygote
- Mice
- Mice, Neurologic Mutants
- Muscles
- Mutation
- Neural Tube Defects