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Article

Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates.

Developmental cell - 1 Jun 2009

Sambasivan Ramkumar, Gayraud-Morel Barbara, Dumas Gérard, Cimper Clémire, Paisant Sylvain, Kelly Robert G, Kelly Robert, Tajbakhsh Shahragim

Abstract excerpt

Genetic regulatory networks governing skeletal myogenesis in the body are well understood, yet their hierarchical relationships in the head remain unresolved. We show that either Myf5 or Mrf4 is necessary for initiating extraocular myogenesis. Whereas Mrf4 is dispensable for pharyngeal muscle progenitor fate, Tbx1 and Myf5 act synergistically for governing myogenesis in this location. As in the body, Myod acts...

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Identifiers

PMID: 19531352
DOI: 10.1016/j.devcel.2009.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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