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Article

Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation.

Disease models & mechanisms - 1 Jan 2009

Merrick Deborah, Stadler Lukas Kurt Josef, Larner Dean, Smith Janet

Abstract excerpt

Examination of embryonic myogenesis of two distinct, but functionally related, skeletal muscle dystrophy mutants (mdx and cav-3(-/-)) establishes for the first time that key elements of the pathology of Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophy type 1C (LGMD-1c) originate in the disruption of the embryonic cardiac and skeletal muscle patterning processes. Disruption of myogenesis occurs...

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Share to Caveolin 3
Share to Dystrophin
Share to Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Muscle Fibers, Skeletal

Share to Muscular Dystrophies

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Source

Open in PubMed Open full text

Identifiers

PMID: 19535499
DOI: 10.1242/dmm.001008
PMCID: PMC2707105

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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