Article

<i>In vivo</i> RyR1 reduction in muscle triggers a core-like myopathy

2020-08-27

Abstract excerpt

Some mutations in the RYR1 gene lead to congenital myopathies, through reduction in this calcium channel expression level, but the functional whole organism consequences of reduction in RyR1 amount have never been studied. We have developed and characterized a mouse model with inducible muscle specific RYR1 deletion. Recombination in the RYR1 gene resulted in a progressive reduction in the protein amount and wa...

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Literature Corpus work: 53d6aa88-a18c-5e35-b86b-21af1fd6a3ad
DOI: 10.1101/2020.08.27.269647

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