Article
Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jun 2017
Eshima Hiroaki, Miura Shinji, Senoo Nanami, Hatakeyama Koji, Poole David C, Kano Yutaka
Abstract excerpt
In skeletal muscle, resting intracellular Ca2+ concentration ([Ca2+]i) homeostasis is exquisitely regulated by Ca2+ transport across the sarcolemmal, mitochondrial, and sarcoplasmic reticulum (SR) membranes. Of these three systems, the relative importance of the mitochondria in [Ca2+]i regulation remains poorly understood in in vivo skeletal muscle. We tested the hypothesis that the capacity for Ca2+ uptake by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.