Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial bioenergetics and intracellular calcium concentration in primary myotubes from mouse models of malignant hyperthermia.

British journal of anaesthesia - 1 Jan 2026

Kaura Vikas, Chang Leon, Hopkins Philip Morgan, Shaw Marie-Anne

Abstract excerpt

BACKGROUND: Malignant hyperthermia (MH) is a potentially fatal hypermetabolic reaction to general anaesthesia arising from skeletal muscle calcium dysregulation. Previous studies of resting cells support an association between MH susceptibility, mitochondrial dysfunction, and defects in fatty acid metabolism, which are understood to be downstream consequences of calcium dysregulation. We hypothesised that in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Energy Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Malignant Hyperthermia

Share to Mitochondria

Share to Mitochondria, Muscle

Share to Muscle Fibers, Skeletal

Share to Oxygen Consumption

Share to Ryanodine Receptor Calcium Release Channel

Source

Open in PubMed Open full text

Identifiers

PMID: 40835558
DOI: 10.1016/j.bja.2025.05.060
PMCID: PMC12851885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial bioenergetics and intracellular calcium concentration in primary myotubes from mouse models of malignant hyperthermia.PMID 40835558Read ↗

Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice.Semantic proximity Read ↗

Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage.Semantic proximity Read ↗

Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals.Semantic proximity Read ↗

Preclinical model systems of ryanodine receptor 1-related myopathies and malignant hyperthermia: a comprehensive scoping review of works published 1990-2019.Semantic proximity Read ↗

Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1Semantic proximity Read ↗

Malignant hyperthermia: a pharmacogenetic disease of Ca++ regulating proteins.Semantic proximity Read ↗

Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia.Semantic proximity Read ↗

Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse.Semantic proximity Read ↗

Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse.Semantic proximity Read ↗

Functional characterization of malignant hyperthermia-associated RyR1 mutations in exon 44, using the human myotube model.Semantic proximity Read ↗

T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function.Semantic proximity Read ↗

Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.