Article
Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 1994
van Deursen J, Ruitenbeek W, Heerschap A, Jap P, ter Laak H, Wieringa B
Abstract excerpt
To understand better the role of the creatine kinase (CK)/phosphocreatine system in muscle bioenergetics, a series of mouse mutants with subnormal muscle CK (M-CK) expression has been generated. Here we compare the phenotypes of mice deficient in M-CK (M-CK-/-) and M-CK leaky-mutant mice, which c...
Topics
- Animals
- Creatine Kinase
- Energy Metabolism
- Gene Expression
- Glycogen
- Mice
- Mice, Knockout
- Mitochondria, Muscle
- Muscles
- Mutagenesis, Insertional
- Phenotype
- RNA, Messenger