Article
Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 1994
van Deursen J, Ruitenbeek W, Heerschap A, Jap P, ter Laak H, Wieringa B
Abstract excerpt
To understand better the role of the creatine kinase (CK)/phosphocreatine system in muscle bioenergetics, a series of mouse mutants with subnormal muscle CK (M-CK) expression has been generated. Here we compare the phenotypes of mice deficient in M-CK (M-CK-/-) and M-CK leaky-mutant mice, which carry a targeted insertion of a hygromycin B-poly(A) resistance cassette in the second M-CK intron. Mice homozygous for...
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